Welcome to Harrisburg International Airport! This medium-sized single runway airport in Middletown, Pennsylvania, about nine miles southeast of Harrisburg is the third-busiest airport in Pennsylvania for passenger enplanements and cargo shipments behind Philadelphia International Airport and Pittsburgh International Airport. All major US airlines offer regular connections to the country's largest hubs such as Charlotte, Chicago O'Hare, Detroit, Newark, Atlanta or Orlando. The three major air car... Welcome to Harrisburg International Airport! This medium-sized single runway airport in Middletown, Pennsylvania, about nine miles southeast of Harrisburg is the third-busiest airport in Pennsylvania for passenger enplanements and cargo shipments behind Philadelphia International Airport and Pittsburgh International Airport. All major US airlines offer regular connections to the country's largest hubs such as Charlotte, Chicago O'Hare, Detroit, Newark, Atlanta or Orlando. The three major air cargo carriers such as FedEx, UPS, and DHL maintain air services at the east end of the airport in an apron area next to the runway with daily connections to their cargo hubs.